Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis
Identifieur interne : 004A00 ( Main/Exploration ); précédent : 004999; suivant : 004A01Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis
Auteurs : Jun Xu [République populaire de Chine] ; Shuqing Zhong [République populaire de Chine] ; Jinghua Liu [République populaire de Chine] ; Li Li [République populaire de Chine] ; Yong Li [République populaire de Chine] ; Xinwei Wu [République populaire de Chine] ; Zhijie Li [République populaire de Chine] ; Peng Deng [République populaire de Chine] ; Jingqiang Zhang [République populaire de Chine] ; Nanshan Zhong [République populaire de Chine] ; Yanqing Ding [République populaire de Chine] ; Yong Jiang [République populaire de Chine]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Chimiokine CXCL9, Chimiokines CXC (métabolisme), Encéphale (anatomopathologie), Encéphale (virologie), Humains, Issue fatale, Mâle, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification).
- MESH :
- anatomopathologie : Encéphale, Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- métabolisme : Chimiokines CXC, Syndrome respiratoire aigu sévère.
- virologie : Encéphale, Syndrome respiratoire aigu sévère.
- Adulte, Chimiokine CXCL9, Humains, Issue fatale, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Chemokines, CXC.
- chemical : Chemokine CXCL9.
- isolation & purification : SARS Virus.
- metabolism : Severe Acute Respiratory Syndrome.
- pathology : Brain, Severe Acute Respiratory Syndrome.
- virology : Brain, Severe Acute Respiratory Syndrome.
- Adult, Fatal Outcome, Humans, Male.
Abstract
Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed that a few patients with severe acute respiratory syndrome (SARS) experienced central nervous symptoms during the course of illness. In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. Methods. Using transmission electronic microscopy and nested reverse transcription–polymerase chain reaction, the causative pathogen was identified in cultures of a brain tissue specimen obtained from the patient with SARS. Histopathologic examination of the brain tissue was performed using the methods of immunohistochemistry analysis and double immunofluorescence staining. Fifteen cytokines and chemokines were detected in the blood of the patient with SARS by means of a bead-based multiassay system. Results. A fragment specific for SARS human coronavirus was amplified from cultures of the brain suspension, and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures. Pathologic examination of the brain tissue revealed necrosis of neuron cells and broad hyperplasia of gliocytes. Immunostaining demonstrated that monokine induced by interferon-Γ (Mig) was expressed in gliocytes with the infiltration of CD68+ monocytes/macrophages and CD3+ T lymphocytes in the brain mesenchyme. Cytokine/chemokine assay revealed that levels of interferon-Γ–inducible protein 10 and Mig in the blood were highly elevated, although the levels of other cytokines and chemokines were close to normal. Conclusions. This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS.
Url:
- https://api.istex.fr/ark:/67375/HXZ-Q28LL5MB-C/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107994
DOI: 10.1086/444461
Affiliations:
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<term>Brain (virology)</term>
<term>Chemokine CXCL9</term>
<term>Chemokines, CXC (metabolism)</term>
<term>Fatal Outcome</term>
<term>Humans</term>
<term>Male</term>
<term>SARS Virus (isolation & purification)</term>
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<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Encéphale (anatomopathologie)</term>
<term>Encéphale (virologie)</term>
<term>Humains</term>
<term>Issue fatale</term>
<term>Mâle</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (métabolisme)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chimiokines CXC</term>
<term>Syndrome respiratoire aigu sévère</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<front><div type="abstract">Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed that a few patients with severe acute respiratory syndrome (SARS) experienced central nervous symptoms during the course of illness. In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. Methods. Using transmission electronic microscopy and nested reverse transcription–polymerase chain reaction, the causative pathogen was identified in cultures of a brain tissue specimen obtained from the patient with SARS. Histopathologic examination of the brain tissue was performed using the methods of immunohistochemistry analysis and double immunofluorescence staining. Fifteen cytokines and chemokines were detected in the blood of the patient with SARS by means of a bead-based multiassay system. Results. A fragment specific for SARS human coronavirus was amplified from cultures of the brain suspension, and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures. Pathologic examination of the brain tissue revealed necrosis of neuron cells and broad hyperplasia of gliocytes. Immunostaining demonstrated that monokine induced by interferon-Γ (Mig) was expressed in gliocytes with the infiltration of CD68+ monocytes/macrophages and CD3+ T lymphocytes in the brain mesenchyme. Cytokine/chemokine assay revealed that levels of interferon-Γ–inducible protein 10 and Mig in the blood were highly elevated, although the levels of other cytokines and chemokines were close to normal. Conclusions. This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS.</div>
</front>
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<name sortKey="Deng, Peng" sort="Deng, Peng" uniqKey="Deng P" first="Peng" last="Deng">Peng Deng</name>
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<name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name>
<name sortKey="Li, Yong" sort="Li, Yong" uniqKey="Li Y" first="Yong" last="Li">Yong Li</name>
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<name sortKey="Liu, Jinghua" sort="Liu, Jinghua" uniqKey="Liu J" first="Jinghua" last="Liu">Jinghua Liu</name>
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<name sortKey="Zhong, Shuqing" sort="Zhong, Shuqing" uniqKey="Zhong S" first="Shuqing" last="Zhong">Shuqing Zhong</name>
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